Abstract
Human CD38 is the mammalian prototype of a family of proteins which share structural similarities and an ectoenzymatic activity involved in the production of calcium mobilizing compounds. Besides the enzymatic activity, the molecule performs as a receptor, ruling adhesion and signaling in leukocytes. These functions are exerted through the interaction with surface ligands, one of which was identified as CD31. Recently, CD38 has gained attention as a prognostic marker and a pathogenetic agent in leukemias and in other diseases. Together these insights have produced a model of an as yet unique family of molecules, which act independently as receptors and enzymes.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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ADP-ribosyl Cyclase
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ADP-ribosyl Cyclase 1
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Animals
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Antigens, CD / immunology
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Antigens, CD / metabolism
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Antigens, CD / physiology
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Antigens, Differentiation / immunology
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Antigens, Differentiation / metabolism
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Antigens, Differentiation / physiology*
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Humans
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Membrane Glycoproteins
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Multienzyme Complexes / immunology
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Multienzyme Complexes / metabolism
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Multienzyme Complexes / physiology
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NAD+ Nucleosidase / immunology
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NAD+ Nucleosidase / metabolism
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NAD+ Nucleosidase / physiology*
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Receptors, Immunologic / immunology
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Receptors, Immunologic / metabolism
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Receptors, Immunologic / physiology
Substances
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Antigens, CD
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Antigens, Differentiation
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Membrane Glycoproteins
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Multienzyme Complexes
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Receptors, Immunologic
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ADP-ribosyl Cyclase
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CD38 protein, human
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NAD+ Nucleosidase
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ADP-ribosyl Cyclase 1