Relationship between grade of microsatellite instability and target genes of mismatch repair pathways in sporadic colorectal carcinoma

Dig Dis Sci. 2001 Aug;46(8):1615-22. doi: 10.1023/a:1010628831884.

Abstract

Microsatellite instability (MSI) induces carcinoma through the alteration of target genes; TGF-beta RII, BAX, IGFIIR, hMSH3, and hMSH6. The grade of M

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Amino Acid Sequence
  • Base Pair Mismatch / genetics*
  • Base Sequence
  • Carcinoma / genetics*
  • Carcinoma / pathology
  • Colorectal Neoplasms / genetics*
  • Colorectal Neoplasms / pathology
  • DNA Repair / genetics*
  • DNA, Neoplasm / genetics*
  • DNA-Binding Proteins / genetics
  • Female
  • Frameshift Mutation*
  • Humans
  • Male
  • Microsatellite Repeats / genetics*
  • Middle Aged
  • Multidrug Resistance-Associated Proteins*
  • MutS Homolog 3 Protein
  • Polymerase Chain Reaction
  • Protein Serine-Threonine Kinases
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins c-bcl-2*
  • Receptor, IGF Type 2 / genetics
  • Receptor, Transforming Growth Factor-beta Type II
  • Receptors, Transforming Growth Factor beta / genetics
  • Transforming Growth Factor beta / genetics*
  • bcl-2-Associated X Protein

Substances

  • BAX protein, human
  • DNA, Neoplasm
  • DNA-Binding Proteins
  • G-T mismatch-binding protein
  • MSH3 protein, human
  • Multidrug Resistance-Associated Proteins
  • MutS Homolog 3 Protein
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-bcl-2
  • Receptor, IGF Type 2
  • Receptors, Transforming Growth Factor beta
  • Transforming Growth Factor beta
  • bcl-2-Associated X Protein
  • Protein Serine-Threonine Kinases
  • Receptor, Transforming Growth Factor-beta Type II
  • multidrug resistance-associated protein 1