Unusual clear cell variant of epithelioid mesothelioma

Arch Pathol Lab Med. 2001 Dec;125(12):1588-90. doi: 10.5858/2001-125-1588-UCCVOE.

Abstract

Clear cell mesothelioma is an extremely rare neoplasm of the pleura, which can easily be mistaken for a metastasis of clear cell carcinoma to the pleura. We report here the histochemical, immunohistochemical, and ultrastructural aspects of a new case of clear cell pleural mesothelioma in a 52-year-old man with no known asbestos exposure. He was admitted to the hospital for recurrent pleural effusion, which was negative for neoplastic cells at the cytologic examination. A partial decortication of the right pleura was performed. The morphologic, immunohistochemical, and ultrastructural features reported for this case are consistent with the diagnosis of clear cell mesothelioma. The differential diagnosis and immunohistochemical features in comparison with other clear cell neoplasms are discussed.

Publication types

  • Case Reports

MeSH terms

  • Biomarkers, Tumor / analysis
  • Calbindin 2
  • Desmosomes / ultrastructure
  • Diagnosis, Differential
  • Epithelioid Cells / chemistry
  • Epithelioid Cells / pathology*
  • Fatal Outcome
  • Humans
  • Immunoenzyme Techniques
  • Male
  • Mesothelioma / chemistry
  • Mesothelioma / pathology*
  • Mesothelioma / surgery
  • Microscopy, Electron
  • Microvilli / ultrastructure
  • Middle Aged
  • Pleural Effusion, Malignant / etiology
  • Pleural Effusion, Malignant / pathology
  • Pleural Neoplasms / chemistry
  • Pleural Neoplasms / pathology*
  • Pleural Neoplasms / surgery
  • S100 Calcium Binding Protein G / analysis

Substances

  • Biomarkers, Tumor
  • Calbindin 2
  • S100 Calcium Binding Protein G