A novel TPMT missense mutation associated with TPMT deficiency in a 5-year-old boy with ALL

Leukemia. 2003 Jul;17(7):1422-4. doi: 10.1038/sj.leu.2402981.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Child, Preschool
  • Family Health
  • Humans
  • Male
  • Mercaptopurine / metabolism
  • Mercaptopurine / therapeutic use
  • Methyltransferases / deficiency
  • Methyltransferases / genetics*
  • Mutation, Missense
  • Pedigree
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / enzymology*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics

Substances

  • Mercaptopurine
  • Methyltransferases
  • thiopurine methyltransferase