Prognostic significance of grading (MIB-1 system) in patients with myxoid liposarcoma

J Clin Pathol. 2003 Aug;56(8):579-82. doi: 10.1136/jcp.56.8.579.

Abstract

Aims: To determine the relation between clinical outcome and tumour grade defined by a MIB-1 (Ki-67) score based grading system.

Method: The clinical and pathological features of 50 patients with myxoid liposarcoma were evaluated, and MIB-1 immunostaining was performed to grade these patients' tumours. Univariate and multivariate analyses were conducted to evaluate survival. Clinical follow up details were available for all patients (median, 46.5 months; range, 9-408).

Results: Univariate analysis revealed that the tumour site (p < 0.05), round cell component content (p < 0.01), necrosis (p < 0.01), mitosis (p < 0.01), MIB-1 labelling index (p < 0.001), and tumour grade (p < 0.001) had a significant impact on overall survival. Multivariate analysis showed that, of the variables evaluated, the tumour grade defined by a MIB-1 score based grading system was the most significant adverse prognostic factor.

Conclusion: Tumour grade determined by the grading system using the MIB-1 score (MIB-1 system) is a very strong prognostic factor in patients with myxoid liposarcoma.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antibodies, Antinuclear / analysis*
  • Antibodies, Monoclonal / analysis*
  • Biomarkers, Tumor / analysis*
  • Female
  • Follow-Up Studies
  • Humans
  • Immunohistochemistry
  • Liposarcoma, Myxoid / chemistry
  • Liposarcoma, Myxoid / mortality
  • Liposarcoma, Myxoid / pathology*
  • Male
  • Middle Aged
  • Necrosis
  • Prognosis
  • Proportional Hazards Models
  • Survival Rate

Substances

  • Antibodies, Antinuclear
  • Antibodies, Monoclonal
  • Biomarkers, Tumor
  • MIB-1 antibody