Abstract
GABARAP and gec1/GABARAPL1 genes encode very similar proteins belonging to a new microtubule-associated protein (MAP) family. These proteins could participate in a complex clustering, targeting and/or degrading the GABA(A) receptors on post-synaptic membrane of neurons. Using specific cDNA probes, we investigated the differential expression of both genes in 76 human tissues. Against all odds, gec1/GABARAPL1 was more expressed than GABARAP in the central nervous system (CNS), while GABARAP was more expressed in endocrine glands.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptor Proteins, Signal Transducing
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Apoptosis Regulatory Proteins
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Cell Membrane / metabolism
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Central Nervous System / metabolism*
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Chromosomes, Human, Pair 12 / genetics
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Chromosomes, Human, Pair 17 / genetics
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Endocrine Glands / metabolism*
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Fetus
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Gene Expression / genetics*
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Humans
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Microtubule-Associated Proteins / genetics*
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Neoplasms / genetics
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Neoplasms / metabolism
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Neurons / metabolism
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RNA, Messenger / metabolism
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Receptor Aggregation / genetics
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Receptors, GABA-A / metabolism
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Synaptic Transmission / genetics
Substances
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Adaptor Proteins, Signal Transducing
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Apoptosis Regulatory Proteins
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GABARAP protein, human
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GABARAPL1 protein, human
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Microtubule-Associated Proteins
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RNA, Messenger
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Receptors, GABA-A