Synchronous ileal and colonic adenocarcinomas associated with Crohn's disease: report of a case with a focus on genetic alterations and carcinogenesis

B Baisse; C Fontolliet; Y S Bian; H Vuilleumier; J Benhattar

doi:10.1136/jcp.2003.014811

Synchronous ileal and colonic adenocarcinomas associated with Crohn's disease: report of a case with a focus on genetic alterations and carcinogenesis

J Clin Pathol. 2004 Aug;57(8):885-7. doi: 10.1136/jcp.2003.014811.

Authors

B Baisse¹, C Fontolliet, Y S Bian, H Vuilleumier, J Benhattar

Affiliation

¹ Institute of Pathology, Centre Hospitalier Universitaire Vaudois, CH-1011 Lausanne, Switzerland.

Abstract

Patients with Crohn's disease have an increased risk of developing intestinal tumours. However, the carcinogenic mechanisms remain poorly understood. To address this question, this report describes an unusual case of Crohn's disease complicated by synchronous small intestinal and colonic adenocarcinomas. Genetic events in both the tumours and their adjacent mucosae were evaluated and the tumorigenesis of these cancers is discussed.

Publication types

Case Reports

MeSH terms

Adenocarcinoma / genetics
Adenocarcinoma / pathology*
Colonic Neoplasms / genetics
Colonic Neoplasms / pathology*
Crohn Disease / complications*
Crohn Disease / genetics
Crohn Disease / pathology*
Cytoskeletal Proteins / analysis
Female
Gene Expression
Humans
Ileal Neoplasms / genetics
Ileal Neoplasms / pathology*
Immunohistochemistry
Intestinal Mucosa / metabolism
Intestinal Mucosa / pathology
Microsatellite Repeats
Middle Aged
Neoplasms, Multiple Primary / genetics
Neoplasms, Multiple Primary / pathology*
Trans-Activators / analysis
beta Catenin

Substances

CTNNB1 protein, human
Cytoskeletal Proteins
Trans-Activators
beta Catenin