Consent of the recently bereaved to post-mortem targeted angiography research: 207 adult cases

J Clin Pathol. 2013 Apr;66(4):326-9. doi: 10.1136/jclinpath-2012-201250. Epub 2012 Dec 8.

Abstract

Aims: To present our experience of prospective telephone consenting for post-mortem CT angiography (PMCT-A) research using HM coroners' cases.

Methods: Local ethics committee, research and development office, and local HM coroners gave their permission for the families of the deceased, in cases where a 'routine' coroner's autopsy had been authorised, to be approached for their consent to PMCT-A research before the autopsy examination. A forensic pathologist or trial consenter telephoned the next of kin, discussed the nature of the study and obtained verbal informed consent for post-mortem imaging, angiography, case-dependent histological and toxicology sampling and for the use of the images for teaching and training. Thematic analyses of the reasons for giving or refusing consent are provided.

Results: Of the 207 cases approached, seven relatives refused to enter their next of kin into the study (96.6% consent rate).

Conclusions: This study shows that prospective consenting for HM coroners' cases to be used for autopsy research is feasible in adults, and can be done ethically, and in the limited time available, by obtaining the consent of the next of kin by telephone before autopsy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Angiography / ethics
  • Angiography / methods*
  • Attitude to Death
  • Autopsy
  • Bereavement*
  • Biomedical Research* / ethics
  • Coroners and Medical Examiners
  • England
  • Family / psychology*
  • Feasibility Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Research Subjects*
  • Telephone
  • Third-Party Consent*
  • Time Factors
  • Tomography, X-Ray Computed* / ethics