Variable bioavailability of oral mercaptopurine. Is maintenance chemotherapy in acute lymphoblastic leukemia being optimally delivered?

N Engl J Med. 1983 Apr 28;308(17):1005-9. doi: 10.1056/NEJM198304283081705.
No abstract available

Publication types

  • Comparative Study

MeSH terms

  • Administration, Oral
  • Adolescent
  • Animals
  • Biological Availability
  • Child
  • Child, Preschool
  • Chromatography, High Pressure Liquid
  • Female
  • Humans
  • Injections, Intravenous
  • Kinetics
  • Leukemia, Lymphoid / drug therapy*
  • Macaca mulatta
  • Male
  • Mercaptopurine / administration & dosage*
  • Mercaptopurine / metabolism
  • Mercaptopurine / therapeutic use

Substances

  • Mercaptopurine