Adenocarcinoid, a mucin-producing carcinoid tumor of the appendix: a study of 39 cases

Cancer. 1978 Dec;42(6):2781-93. doi: 10.1002/1097-0142(197812)42:6<2781::aid-cncr2820420638>3.0.co;2-b.

Abstract

Adenocarcinoid is a form of appendiceal carcinoid possessing features of both carcinoid and adenocarcinoma. There are two histologic types. Thirty patients had the goblet cell type, characterized by nests of large mucin-distended cells. Nine patients had the tubular type, characterized by small glandular structures lined by uniform cells. Despite abundant mucin and a goblet cell or acinar-like arrangement, a closer relationship to carcinoid than to adenocarcinoma is suggested by a concentration of tumor elements below the crypts of Lieberkuhn, a lack of evidence of neoplastic transformation of the appendiceal mucosa, and the demonstration of argentaffin or argyrophil granules in 88% of the lesions. Six tumors, all of the goblet cell type, metastasized and resulted in the death of the patients. One of the tumours that metastasized had a prominent tubular component. Most adenocarcinoids can be adequately treated by appendectomy, but hemicolectomy is recommended for those tumors showing atypical foci, a high mitotic count, or spread beyond the appendix.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / metabolism
  • Adenocarcinoma / pathology*
  • Adenocarcinoma / surgery
  • Adult
  • Aged
  • Appendiceal Neoplasms / metabolism
  • Appendiceal Neoplasms / pathology*
  • Appendiceal Neoplasms / surgery
  • Carcinoid Tumor / metabolism
  • Carcinoid Tumor / pathology*
  • Carcinoid Tumor / surgery
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mucins / biosynthesis*

Substances

  • Mucins