Abstract
In human cervical neoplasia human papillomavirus (HPV) type 18 has a higher cancer/cervical intraepithelial neoplasia (CIN) prevalence ratio than HPV 16. Fibrosarcomas derived from rat fibroblasts transfected with HPV 16 or 18 genomes showed increased apoptosis compared with controls. However, HPV 18 was associated with significantly less apoptosis than HPV 16, affording one possible explanation for the more rapidly progressive cervical neoplasia associated with HPV 18.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Apoptosis / physiology*
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Fibrosarcoma / metabolism
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Fibrosarcoma / pathology
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Fibrosarcoma / virology*
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Genome, Viral
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Humans
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Lung Neoplasms / metabolism
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Lung Neoplasms / pathology
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Lung Neoplasms / virology*
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Mice
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Mice, Inbred CBA
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Oncogene Proteins, Viral / genetics
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Oncogene Proteins, Viral / metabolism
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Papillomaviridae / genetics*
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Papillomaviridae / metabolism
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Papillomavirus Infections / genetics
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Rats
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Rats, Inbred F344
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Transfection
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Tumor Cells, Cultured
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Tumor Virus Infections / genetics