Pathologist variation in reporting cervical borderline epithelial abnormalities and cervical intraepithelial neoplasia

J Clin Pathol. 1995 Jan;48(1):59-60. doi: 10.1136/jcp.48.1.59.

Abstract

Aims: To evaluate the interobserver variation in the diagnosis of cervical intraepithelial lesions, including the new category "borderline abnormalities of uncertain significance" (BAUS) which has not been tested before.

Methods: Biopsy specimens of 122 patients were reviewed by five histopathologists and the diagnoses subjected to kappa statistical analysis.

Results: There was poor interobserver agreement in all categories, particularly between BAUS and normal tissue.

Conclusions: The current guidelines for the histological diagnosis of cervical intraepithelial neoplasia and BAUS are poorly reproducible.

MeSH terms

  • Biopsy
  • Cervix Uteri / pathology*
  • Female
  • Humans
  • Observer Variation
  • Papillomaviridae
  • Papillomavirus Infections / pathology
  • Tumor Virus Infections / pathology
  • Uterine Cervical Dysplasia / classification
  • Uterine Cervical Dysplasia / pathology*
  • Uterine Cervical Neoplasms / classification
  • Uterine Cervical Neoplasms / pathology*