Epithelial-myoepithelial carcinoma of the salivary glands. A study of 22 cases

Virchows Arch A Pathol Anat Histopathol. 1993;422(5):389-96. doi: 10.1007/BF01605458.

Abstract

Twenty-two cases of epithelial-myoepithelial carcinoma of major and minor salivary glands were studied retrospectively to define the clinico-pathological profile and to assess the value of DNA ploidy as a prognostic tool. Fifty-nine percent of the cases occurred in the major salivary glands, the patients being mostly females in their 5th to 8th decades. The clinical course was characterized by a high number of recurrences (in 50% of cases). Death due to the neoplastic disease was found in 40% of the patients. The only morphological feature found to be correlated to prognosis was the presence of nuclear atypia in more than 20% of the tumour cells. In 18 cases, cytophotometric DNA analysis was performed; 15 cases had a diploid DNA histogram and 3 an aneuploid one. All the cases that were DNA aneuploid were of the solid, predominantly clear-cell type and were associated with fatal outcome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Carcinoma / genetics
  • Carcinoma / pathology*
  • DNA, Neoplasm / genetics*
  • Female
  • Humans
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Ploidies
  • Prognosis
  • Retrospective Studies
  • Salivary Gland Neoplasms / genetics
  • Salivary Gland Neoplasms / pathology*

Substances

  • DNA, Neoplasm