RT Journal Article
SR Electronic
T1 Cellular types in acute leukaemia: diagnosis and significance
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 325
OP 331
DO 10.1136/jcp.16.4.325
VO 16
IS 4
A1 F. W. Gunz
A1 A. F. Burry
YR 1963
UL http://jcp.bmj.com/content/16/4/325.abstract
AB Two independent observers, one using haematological and the other histological methods, analysed material from 68 patients with acute leukaemia. A correct diagnosis of the cell type of leukaemia was made in 70% of cases by haematological methods, and in 83% of those cases histological examination gave the same result. In two-thirds of the haematologically equivocal cases histological examination provided a positive diagnosis. The finally undiagnosed cases amounted to 12% of the total. The types so diagnosed could not be correlated with any clinical features. Differentiation of the cell types in acute leukaemia showed that children with granulocytic types of acute leukaemia survived for shorter periods than those with other types but in adults the type of cell had no significance when related to survival. In adults the immediate prognosis for all cell types was relatively bad. The unfavourable prognosis attached to a high initial leucocyte count was confirmed.