RT Journal Article
SR Electronic
T1 Cystinosis: electron microscopic evidence of lysosomal storage of cystine in lymph node
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 571
OP 575
DO 10.1136/jcp.21.5.571
VO 21
IS 5
A1 A. D. Patrick
A1 B. D. Lake
YR 1968
UL http://jcp.bmj.com/content/21/5/571.abstract
AB Electron microscopic examination of a biopsy specimen of cystinotic lymph node demonstrated that cystine crystals were entirely intracellular, and that the majority, including those of the largest size, were enclosed by intact limiting membranes. Acid phosphatase activity was localized specifically at the periphery of the crystal profiles and the smallest crystal aggregates were contained in osmophilic dense bodies which had the appearance of progressively swollen lysosomes. The implications of the suggested lysosomal distribution of cystine are discussed.