PT  - JOURNAL ARTICLE
AU  - J. R. O'Brien
AU  - Wendy Finch
AU  - Elizabeth Clark
TI  - A comparison of an effect of different anti-inflammatory drugs on human platelets
AID  - 10.1136/jcp.23.6.522
DP  - 1970 Sep 01
TA  - Journal of Clinical Pathology
PG  - 522--525
VI  - 23
IP  - 6
4099  - http://jcp.bmj.com/content/23/6/522.short
4100  - http://jcp.bmj.com/content/23/6/522.full
SO  - J Clin Pathol1970 Sep 01; 23
AB  - Different doses of aspirin, indomethacin, paracetamol, benorylate, and sodium salicylate were taken by four volunteers. The minimal dose that altered a platelet function test and the persistence of this alteration at different dose levels were studied. Minute doses of indomethacin (0·035 mg/kg) were effective but the effect of even a large single dose did not persist. A tenth of the therapeutic dose of aspirin (1 mg/kg) was effective, and higher doses altered the platelets' function for several days. Benorylate in a high therapeutic dose gave aspirin-like results. Paracetamol and sodium salicylate were relatively inactive. The persistence of the aspirin effect may be related to the acetyl group. These findings are surveyed in relation to a general theory of the action of anti-inflammatory drugs.