RT Journal Article
SR Electronic
T1 Serum α-macroglobulins in renal disease and preeclampsia
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 590
OP 593
DO 10.1136/jcp.25.7.590
VO 25
IS 7
A1 C. H. W. Horne
A1 J. D. Briggs
A1 P. W. Howie
A1 A. C. Kennedy
YR 1972
UL http://jcp.bmj.com/content/25/7/590.abstract
AB The serum levels of α2-macroglobulin and pregnancy-associated globulin (another α-macroglobulin) have been measured by means of a radial immunodiffusion technique in (1) renal disease with and without proteinuria, (2) in age- and sex-matched controls, (3) in preeclampsia with and without proteinuria, and (4) in normal pregnant controls. There are significant increases in α2-macroglobulin and pregnancy-associated globulin in renal disease accompanied by proteinuria but normal levels are found in renal disease without proteinuria. Compared with normal pregnancy, α2-macroglobulin is significantly raised in preeclampsia with proteinuria but normal in preeclampsia without proteinuria. In contrast, serum pregnancy-associated globulin is significantly reduced in preeclampsia both with and without proteinuria when compared with normal pregnancy.