PT  - JOURNAL ARTICLE
AU  - R E Clark
AU  - T G Hoy
AU  - A Jacobs
TI  - Granulocyte and monocyte surface membrane markers in the myelodysplastic syndromes.
AID  - 10.1136/jcp.38.3.301
DP  - 1985 Mar 01
TA  - Journal of Clinical Pathology
PG  - 301--304
VI  - 38
IP  - 3
4099  - http://jcp.bmj.com/content/38/3/301.short
4100  - http://jcp.bmj.com/content/38/3/301.full
SO  - J Clin Pathol1985 Mar 01; 38
AB  - The expression of lineage specific surface antigens on granulocytes and monocytes was quantitated using monoclonal antibodies in 16 healthy adults and 21 patients with myelodysplastic syndromes. In nine of 19 patients the granulocytes showed a decrease in myeloid or an increase in monocyte antigen expression or both. In 11 of 19 patients the monocytes showed a decreased expression of monocyte antigens or an increase in myeloid antigens or both. The data suggest that in the myelodysplastic syndromes the granulocyte-macrophage progenitors do not develop along two divergent lines but differentiate with the emergence of dual characteristics.