RT Journal Article
SR Electronic
T1 Utility of immunohistochemical analysis for cyclo-oxygenase 2 in the differential diagnosis of osteoblastoma and osteosarcoma
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 410
OP 414
DO 10.1136/jcp.2006.038828
VO 60
IS 4
A1 Ako Hosono
A1 Umio Yamaguchi
A1 Atsushi Makimoto
A1 Makoto Endo
A1 Atsuko Watanabe
A1 Tadakazu Shimoda
A1 Mitsunori Kaya
A1 Tadaki Matsumura
A1 Hiroshi Sonobe
A1 Tomomi Kusumi
A1 Takehiko Yamaguchi
A1 Tadashi Hasegawa
YR 2007
UL http://jcp.bmj.com/content/60/4/410.abstract
AB Aims: To study the immunoexpression of cyclo-oxygenase (COX) 2 in osteoblastomas (OBs) and osteosarcomas (OSs), and to assess the utility of immunohistochemical analysis for COX 2 in the differential diagnosis of the two tumour forms. Methods: The immunohistochemical features of COX 2 were studied in 11 OBs and 30 OSs, including 26 high-grade OSs (16 osteoblastic, 7 chondroblastic, and 3 fibroblastic) and 4 low-grade OSs. Results: Tumour cells from all 11 OBs unequivocally showed diffuse, intense and cytoplasmic immunoreactivity for COX 2. Strong cytoplasmic expression of COX 2 was observed in 5 of 26 (19%) high-grade OSs, all chondroblastic. In one osteoblastic-type OS, COX 2 was expressed in the chondroblastic component, but this tumour was considered to be COX 2 negative. No COX 2 expression was noted in atypical osteoblastic cells. Staining in the four low-grade OSs was negative. Conclusion: The results of immunohistochemical analysis of COX 2 suggest that in addition to the routine histopathological evaluation, COX 2 is a valuable diagnostic marker in the distinction between OB and OS.