RT Journal Article
SR Electronic
T1 Molecular characteristics and potential therapeutic targets in Merkel cell carcinoma
JF Journal of Clinical Pathology
JO J Clin Pathol
FD BMJ Publishing Group Ltd and Association of Clinical Pathologists
SP 382
OP 390
DO 10.1136/jclinpath-2015-203467
VO 69
IS 5
A1 Shakuntala H Mauzo
A1 Renata Ferrarotto
A1 Diana Bell
A1 Carlos A Torres-Cabala
A1 Michael T Tetzlaff
A1 Victor G Prieto
A1 Phyu P Aung
YR 2016
UL http://jcp.bmj.com/content/69/5/382.abstract
AB Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin tumour occurring preferentially in elderly and immunosuppressed individuals. Multiple studies have provided insight into the molecular alterations of MCC, leading to the design of several ongoing clinical trials testing chemotherapy, targeted therapy and immunotherapy in patients with recurrent or metastatic disease. The results of some of these studies are available, whereas others are eagerly awaited and will likely shed light on the understanding of MCC biology and potentially improve the clinical outcomes of patients with this rare disease.