PT  - JOURNAL ARTICLE
AU  - Elisabetta Kuhn
AU  - Ayse Ayhan
TI  - Diagnostic immunohistochemistry in gynaecological neoplasia: a brief survey of the most common scenarios
AID  - 10.1136/jclinpath-2017-204787
DP  - 2017 Dec 07
TA  - Journal of Clinical Pathology
PG  - jclinpath-2017-204787
4099  - http://jcp.bmj.com/content/early/2017/12/07/jclinpath-2017-204787.short
4100  - http://jcp.bmj.com/content/early/2017/12/07/jclinpath-2017-204787.full
AB  - Immunohistochemistry is a valuable adjunct in routine gynaecological pathology. The molecular revolution has redesigned knowledge of gynaecological cancers and refined histological classification. The direct consequence has been the progressive introduction of new immunostainings for diagnostic and classification purposes. Hence, we review the routine diagnostic use of immunohistochemistry in the field of gynaecological neoplasia. We reviewed the immunomarkers useful in gynaecological pathology according to literature revision, our personal experience and research findings. We discuss the application of immunohistochemistry to reach the most accurate diagnosis in morphologically equivocal cases of gynaecological pathology and present the appropriate panel of immunomarkers in the most common scenarios of gynaecological pathology. This short review provides an updated overview of the essential immunohistochemical markers currently used in the diagnostics of gynaecological malignancies along with their molecular rationale.