Table 3

Details of cases with p53 mutations

p53 mutation
CaseMSIp53 LOHExonCodonBase changeNomenclatureAmino acid change
MSI, microsatellite instability; MSI++, MSI high; MSI+, MSI low; MSI−, MSI negative; NI, not informative; bp, base pair; del, deletion; ins, insertion; LOH, loss of heterozygosity; LOH+, LOH positive; LOH−, LOH negative; Mis, Missense mutation; Frame, Frameshift mutation.
29++NI6198GAA → CAAMisArg → His
39+++5175CGC → CACMisArg → His
72+++5132−13616 bp delFrameStop at 164
82++−7248CGG → TGGMisArg → Trp
102+++5175CGC → CACMisArg → His
151+++5146TGG → TCGMisTrp → Ser
27++51471 bp insFrameStop at 148
31++6205TAA → AATMisTyr → Asn
15−+8273CGT → CATMisArg → His
26−−5170ACG → TCGMisThr → Ser
30−+5175CGC → CACMisArg → His
67−NI6221GAG → CAGMisGlu → Gln
69−−5170ACG → TCGMisThr → Ser
77−+5175CGC → CACMisArg → His
109−+5175CGC → CACMisArg → His
110−−7248CGG → CTGMisArg → Leu
111−+8273CGT → CATMisArg → His
112−+6208GAC → GTCMisAsp → Val
136−+8282CGG → TGGMisArg → Trp