Summary of frequency of somatic changes in microsatellite instability (MSI) high, MSI low, and MSI negative non-familial colorectal carcinomas
| No. of tumours with somatic changes | ||||||
|---|---|---|---|---|---|---|
| Mutation/informative tumours (%) | LOH/informative tumours (%) | |||||
| MSI type | No. of tumours analysed | APC | p53 | Ki-ras | 17p | LOH of 17p/p53 mutation (%) |
| Sequence accession numbers by Genebank (APC, M74088; p53, M14694; Ki-ras, M34904). | ||||||
| LOH, loss of heterozygosity. | ||||||
| MSI high | 24 | 11/24 (46) | 6/22 (27) | 2/24 (8) | 9/23 (39) | 4/6 (67) |
| MSI low | 9 | 4/9 (44) | 2/7 (28) | 4/9 (44) | 4/8 (50) | 1/2 (50) |
| MSI negative | 31 | 10/31 (32) | 11/29 (38) | 11/29 (38) | 11/26 (42) | 7/11 (64) |
| p Value, MSI high v MSI low and MSI negative | 0.4 | 0.4 | 0.008 | 0.68 | >0.999 | |