Table 3

Clinical, morphological, and biological data of node positive women T1–4 N+ M0 (n = 161)

	p21^waf negative		p21^waf positive		Total
	n	%	n	%	n	%	p Value
Univariate statistical calculation using χ² test.
Receptor status: positive, ER positive and/or PR positive; negative, ER negative and PR negative; detection by immunohistochemistry.
Steroid hormone receptor status was determined in 158 women, PCNA in 158, Her2/neu expression in 156, and p53 expression in 156 samples.
ER, oestrogen receptor; NS, not significant; PCNA, proliferating cell nuclear antigen; PR, progesterone receptor.
Age (years)
< 50	34	21.1	22	13.7	56	34.8
> 50	75	46.6	30	18.6	105	65.2	NS
Menopausal status
Pre	29	18.0	18	11.2	47	29.2
Peri	12	7.5	8	5.0	20	12.4
Post	68	42.2	26	16.1	94	58.4	NS
Tumour size (cm)
< 2	30	18.6	17	10.6	47	29.2
> 2–5	57	35.4	25	15.5	82	50.9
> 5	22	13.7	10	6.2	32	19.9	NS
Tumour grade
GI	18	11.2	6	3.7	24	14.9
GII	49	30.4	32	19.9	81	50.3
GIII	42	26.1	14	8.7	56	34.8	NS
Receptor status
Negative	39	24.7	14	8.9	53	33.5
Positive	69	43.7	36	22.8	105	66.5	NS
PCNA
< 10%	46	29.1	19	12.0	65	41.1
10–49%	35	22.2	14	8.9	49	31.0
> 50%	26	16.5	18	11.4	44	27.8	NS
Her2/neu
Negative	78	50.0	39	25.0	117	75.0
Positive	28	30.1	11	7.1	39	25.0	NS
p53
Negative	59	37.8	29	18.6	88	56.4
Positive	47	30.1	21	13.5	68	43.6	NS
p21^waf	109	67.7	52	32.3