CD117/c-kit positive tumours (adapted from Chan 1 )
| CD117/c-kit positivity, in the setting of an appropriate immunohistochemical panel, is very useful in resolving the differential diagnosis of gastrointestinal spindle cell tumours. Nevertheless, it is important to remember that this antigen is present in a variety of different tumours, particularly in the context of metastatic disease. |
| Gastrointestinal tumours |
| • Gastrointestinal stromal tumours |
| Tumours occurring primarily outside the gastrointestinal tract |
| • Melanoma (loss in vertical growth phase and metastases) |
| • Clear cell sarcoma of tendons and aponeuroses |
| • Endometrial carcinoma |
| • Anaplastic small cell carcinoma of the lung |
| • Ewing's sarcoma group |
| • Anaplastic large cell lymphoma |
| • Reed-Sternberg cell in Hodgkin's lymphoma |
| • Mastocytosis |
| • Acute myeloid leukaemia |
| • Glioma |
| • Germinoma |