Proportion of CIN samples with transcripts
| No. positive samples (% positive) | Positive predictive value and specificity for CIN 2/3 | ||||
|---|---|---|---|---|---|
| Transcript | CIN 0/1 (n = 17) | CIN 2/3 (n = 40) | p Value | PPV | Specificity |
| The table shows the proportion of colposcopy samples containing HPV-16 that contained detectable amounts of the transcripts shown. The number in each group (n) is shown. | |||||
| HPV-16 transcripts are E6, E6*I, E6*II, E7, and L1. E6 and E7 encode the full length functional protein, whereas E6*I and E6*II encode truncated E6 proteins whose functions are uncertain. | |||||
| Cellular transcripts are telomerase reverse transcriptase (hTERT), telomerase RNA component (hTR), and survivin. | |||||
| p Values were calculated using χ2 analysis. | |||||
| Also shown are the subsequent positive predictive value (PPV) and specificity in determining CIN 2/3 for each transcript. | |||||
| Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) transcripts were detected in all samples. | |||||
| E6 | 6.00 (35.3) | 29.00 (72.5) | 0.01 | 82.90 | 64.70 |
| E6*I | 2.00 (11.8) | 17.00 (42.5) | 0.01 | 89.50 | 88.20 |
| E6*II | 0.00 (0) | 10.00 (25) | 0.04 | 100.00 | 100.00 |
| E7 | 5.00 (29.4) | 24.00 (60) | 0.04 | 82.80 | 70.60 |
| L1 | 6.00 (35.3) | 23.00 (57.5) | 0.13 | 79.30 | 64.70 |
| hTERT | 1.00 (5.9) | 0.00 (0) | 0.12 | 0.00 | 94.10 |
| hTR | 14.00 (82.4) | 37.00 (92.5) | 0.25 | 72.50 | 17.60 |
| Survivin | 8.00 (47.1) | 15.00 (37.5) | 0.50 | 65.20 | 52.90 |