Patients (n = 83) | ||||
---|---|---|---|---|
Locus | Genotype | ureA+(n = 62) | ureA−(n = 21) | Healthy controls (n = 113) |
In a 2 × 2 analysis, possession of TNF-308A was associated with an odds ratio of 2.912 (95% confidence interval, 1.082 to 7.836; χ2 = 4.505; p = 0.034) for ureA+ versus healthy controls. | ||||
−308 | G/G | 52 (83.9%) | 21 (100%) | 106 (93.8%) |
G/A | 9 (14.5%) | 0 | 7 (6.2%) | |
A/A | 1 (1.6%) | 0 | 0 | |
Allele frequencies for −308A | 0.0887 | 0 | 0.0309 | |
−238 | G/G | 58 (93.5%) | 20 (95.2%) | 100 (88.5%) |
G/A | 4 (6.5%) | 1 (4.8%) | 12 (10.6%) | |
A/A | 0 | 0 | 1 (0.9%) | |
Allele frequencies for −238A | 0.0323 | 0.0238 | 0.0619 |