Association of Helicobacter pylori cagA subtype with tumour necrosis factor α (TNF-α) promoter polymorphisms at positions −308 and −238 in patients with gastric disease
| Patients | |||
|---|---|---|---|
| Locus | Genotype | cagA+(n = 46) | cagA−(n = 37) |
| In a 2 × 2 analysis for cagA+ versus healthy controls, possession of TNF-308A was associated with an odds ratio (OR) of 3.683 (95% confidence interval (CI), 1.343 to 10.101; χ2 = 6.458; p = 0.011). For cagA+ versus cagA−, TNF-308A was associated with an OR of 8.757 (95% CI, 1.413 to 54.262; χ2 = 5.502; p = 0.019). | |||
| −308 | G/G | 37 (80.4%) | 36 (97.3%) |
| G/A | 8 (17.4%) | 1 (2.7%) | |
| A/A | 1 (2.2%) | 0 | |
| Allele frequencies for −308A | 0.1087 | 0.0135 | |
| −238 | G/G | 43 (93.5%) | 35 (94.6%) |
| G/A | 3 (6.5%) | 2 (5.4%) | |
| A/A | 0 | 0 | |
| Allele frequencies for −238A | 0.0326 | 0.0270 | |