Autoantibodies in scleroderma
| Autoantibody | Clinical importance |
|---|---|
| Anti-DNA topoisomerase I (Scl-70) | Diffuse scleroderma |
| Anticentromere (proteins A, B C) | Limited scleroderma |
| Anti-U3RNP (fibrillarin) | Diffuse scleroderma—severe disease |
| Anti-7-2/8-2 RNP (Th/To) | Limited scleroderma |
| Anti-RNA polymerases I, II, III | Diffuse scleroderma, renal crisis |
| Anti-PM-Scl | Scleroderma overlap |
| Anti-U2 RNP | Scleroderma overlap |
| Anti-Ku | Scleroderma overlap |
| Antipyruvate dehydrogenase complex (M2) | Limited scleroderma and scleroderma overlap |