Tumour characteristics | Morphology after chemoradiotherapy |
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Architecture | Dissociated tubules, short lines, or single cells in a fibrotic stroma. In mucinous tumours, cells were discohesive and suspended in pools of mucin |
Nucleus | Very large and bizarrely shaped with multiple lobes and a “popcorn”-like appearance. Chromatin was vesicular. Nucleoli were large and often multiple |
Cytoplasm | Dense, granular, and eosinophilic or vacuolated. There was merging of cytoplasm of adjacent cells |