Patient with STK11/LKB1 germline mutation | 19p LOH | 5q LOH/APC mutational analysis (DGGE) | K-ras codon 12 mutation | 18q LOH/IHC Smad 4 expression | 17p LOH/IHC p53 overexpression/p53 mutation exons 5–8 | |
---|---|---|---|---|---|---|
*Fragment S4 from the APC mutation cluster region is non-informative. | ||||||
DGGE, denaturing gradient gel electrophoresis; LOH, loss of heterozygosity. | ||||||
Stomach carcinoma | Unknown | + | −/+ | − | −/+ | −/−/− |
Small bowel carcinoma | + | + | −/−* | − | −/+ | −/+/− |
Pancreas carcinoma | + | + | −/+ | − | −/+ | −/−/− |
Colon carcinoma | + | + | −/+ | − | +/+ | −/−/− |
Colon carcinoma (fresh frozen) | Unknown | + | −/+ (truncationof segment 2) | + | −/+ | −/−/− |