Table 3

Microsatellite instability (MSI), Matts's classification, and p53 overexpression in ulcerative colitis of long duration with neoplasm (neoplastic and inflamed epithelium)

Patient no.Region no.ClassABCDEFTotal MSIGMatts's score p53 over expression
Microsatellite markers: A, D2S123; B, D2S1611; C, BAT26; D, Mfd26; E, TP53; F, D3S1629; G, TGFβRII (poly A). MSI is indicated by an sterisk. Ca, carcinoma; HGD, high grade dysplasia; IFD-N, indefinite for dysplasia, probably negative; IFD-P, indefinite for dysplasia, probably positive; LGD, low grade dysplasia.
11Ca**2(−)
HGD*1(−)
LGD0(−)
IFD-P0(−)
N*11(−)
N*12(−)
2HGD0(++)
LGD*1(++)
N03(−)
N*11(−)
N01(−)
N*11(−)
N01(−)
21Ca***3(++)
N01(−)
2HGD0(+)
LGD**2(+)
IFD-P0(−)
N***31(−)
N*11(−)
N**23(−)
31Ca0(++)
HGD0(++)
LGD*1(++)
IFD-P0(++)
N*11(−)
2HGD0(−)
IFD-P*1(−)
3LGD0(−)
4IFD-P0(−)
N*11(−)
N*11(−)
N*12(−)
41Ca0(++)
HGD0(++)
IFD-N*1(−)
N03(−)
N02(−)
N02(−)
N*12(−)
N*13(−)
51HGD0(−)
LGD*1(++)
IFD-P0(−)
IFD-P0(++)
IFD-N0(−)
N01(−)
N02(−)
N01(−)