Synopsis of human papillomavirus (HPV) status of 12 cervical large cell neuroendocrine carcinomas by NISH and PCR
| NISH | PCR | |||||||
|---|---|---|---|---|---|---|---|---|
| HPV E6, type specific† | ||||||||
| Case No. | HPV type | Signal type | HPV L1 | HPV E6/E7 (benign group) | HPV E6/E7 (malignant group) | HPV E6/E7, type specific* (HPV type) | HPV-16 | HPV-18 |
| HPV types 6, 11, 31, and 33 were not detected with NISH. | ||||||||
| *HPV types 6, 11, 31, 33, 52b, and 58 were not detected with this restriction endonuclease digestion system; †HPV type 33 not detected. | ||||||||
| NISH, non-isotopic in situ hybridisation; PCR, polymerase chain reaction. | ||||||||
| 1 | 16 | 2 | + | − | − | − | ||
| 2 | Negative | − | − | − | − | − | ||
| 3 | 16 | 2, 3 | + | − | + | 16 | + | − |
| 4 | Negative | − | − | − | − | − | ||
| 5 | Negative | + | − | − | + | − | ||
| 6 | Negative | − | − | − | − | − | ||
| 7 | 16 | 2, 3 | + | − | + | 16 | + | − |
| 8 | Negative | + | − | + | 16 | + | − | |
| 9 | 18 | 2 | + | − | + | 18 | − | + |
| 10 | Negative | + | − | + | 18 | − | + | |
| 11 | 16 | 2 | + | − | + | 16 | + | − |
| 12 | 16 | 2 | + | − | + | 16 | + | − |