Correlation between clinicopathological findings and cathepsin D (CD) expression
| Variables | CD positive cases (%) | p Value | p53 positive cases (%) | p Value |
|---|---|---|---|---|
| *The 154 patients were divided into two subgroups according to the median tumour size (5 cm). | ||||
| Tumour size (cm)* | ||||
| Small (≤5, n=79) | 37 (47) | 0.522 | 38 (48) | 0.498 |
| Large (>5, n=75) | 39 (52) | 32 (43) | ||
| Histopathological grading | ||||
| G1 (n=9) | 7 (78) | 5 (56) | ||
| G2 (n=66) | 32 (49) | 0.29 | 25 (38) | 0.253 |
| G3 (n=79) | 37 (47) | 40 (51) | ||
| Depth of tumour invasion | ||||
| pTis, pT1 (n=46) | 18 (39) | 17 (37) | ||
| pT2 (n=24) | 10 (42) | 0.15 | 13 (54) | 0.346 |
| pT3 (n=49) | 26 (53) | 21 (43) | ||
| pT4 (n=35) | 22 (63) | 19 (54) | ||
| Lymph node metastasis | ||||
| Absent (n=72) | 33 (46) | 0.413 | 30 (42) | 0.376 |
| Present (n=82) | 43 (52) | 40 (49) | ||
| Distant metastasis | ||||
| Absent (n=146) | 73 (50) | 0.491 | 67 (46) | 0.643 |
| Present (n=8) | 3 (38) | 3 (38) | ||