Mean values (SD) and significance of differences between variables in age matched subjects and controls, and patients with HS
| Variable | Subjects (n=34) | Controls (n=34) | HS patients (n=14) | p Value (subjects/controls) | p Value (HS/controls) | p Value (subjects/HS patients) |
|---|---|---|---|---|---|---|
| Hb, haemoglobin; HDW, haemoglobin distribution width; HS, hereditary spherocytosis; MCH, mean cell heamoglobin; MCHC, mean cell haemoglobin concentration; MCV, mean cell volume; NS, not significant; RBC, red blood cells; RDW, red blood cell distribution width. | ||||||
| Hb (g/l) | 131 (12) | 127 (7) | 112 (14) | NS | <0.0001 | <0.001 |
| MCV (fl) | 79.3 (2.0) | 82.0 (5.8) | 78.3 (3.5) | <0.02 | <0.05 | NS |
| MCH (pg) | 27.9 (1.3) | 27.8 (2.0) | 28.5 (1.6) | NS | NS | NS |
| MCHC (g/l) | 351 (1.0) | 339 (0.9) | 366 (1.6) | <0.0001 | <0.001 | <0.01 |
| RDW (%) | 12.7 (0.6) | 13.0 (1.0) | 18.4 (3.9) | NS | <0.001 | <0.0001 |
| HDW (g/l) | 29.8 (1.8) | 25.6 (2.7) | 41.5 (7.2) | <0.0001 | <0.0001 | <0.0001 |
| Hyperchromic RBC (×109/l) | 329 (245) | 51.8 (47) | 1193 (579) | <0.0001 | <0.0001 | <0.0001 |
| Reticulocytes (×109/l) | 102.8 (44.8) | 76.0 (32.6) | 445.7 (131.2) | <0.01 | <0.0001 | <0.0001 |
| Haemolysis (%) | 18.4 (11.0) | 14.3 (10.3) | 81.9 (15.2) | NS | <0.0001 | <0.0001 |