Cytological features associated with intravesical chemotherapy and low grade urothelial tumours
| Feature | Thiotepa, mitomycin C | Low grade urothelial tumour |
|---|---|---|
| Cellularity | Early: high | Usually high |
| Late: low | ||
| Cell size | Enlarged | Normal to minimal enlargement |
| Nuclear/cytoplasmic ratio | Normal | Increased |
| Staining | Hyperchromatic | Hyperchromatic |
| Nuclear borders | Irregular | Irregular |
| Chromatin | Fine, regular | Fine, regular |
| Nucleoli | Variable | Variable |
| Multinucleated cells and vacuolated cytoplasm | Common | Rare |
| Architecture | Loose, dyscohesive | Papillary and loose clusters |
| DNA ploidy | Diploid | Usually diploid |