Test characteristics of telomerase components and HPV when used for the detection of CIN II/III in women referred because of cervical cytology reports showing at most moderate dyskaryosis
| Test characteristics in % (95% confidence interval) | ||||
|---|---|---|---|---|
| Sensitivity | Specificity | PPV | NPV | |
| Telomerase activity was classed as present when >10 U/μg protein was found. | ||||
| CIN, cervical intraepithelial neoplasia; HPV, human papillomavirus; hTERT, human telomerase reverse transcriptase mRNA; hTR, human telomerase RNA; NVP, negative predictive value; PPV, positive predictive value. | ||||
| Telomerase activity | 0 (0 to 12) | 95 (77 to 100) | 0 | 43 (29 to 58) |
| hTR expression | 88 (69 to 98) | 0 (0 to 15) | 50 (35 to 65) | 0 (0 to 71) |
| hTERT mRNA expression | 28 (12 to 49) | 78 (60 to 95) | 58 (31 to 89) | 49 (33 to 67) |
| High risk HPV | 79 (59 to 92) | 50 (28 to 72) | 67 (48 to 82) | 65 (38 to 86) |