Pathological changes associated with gene therapy
| • | Various degrees of necrosis in cancer foci with loss of chromatin detail and nucleoli in the earlier phases following treatment |
| • | In the late phases, the nuclei shrink, become pyknotic, and acquire a spindled morphology |
| • | Normal urothelial mucosa is rarely affected by necrosis |
| • | Intense chronic inflammatory infiltrate composed predominantly of B cells in the lamina propria |