Correlation (Spearman’s test) between the biomarkers and DNA analysis results
| MNA10 | Ki67 | MAI | p53 | DI FCM | SPF FCM | DI ICM | SPF ICM | ||
|---|---|---|---|---|---|---|---|---|---|
| Note the strong correlation (R>0.65, bold) for the in situ biomarkers with each other, but not with the DNA cytometric features (either by ICM or FCM). | |||||||||
| DI, DNA index; FCM, flow cytometry; ICM, image cytometry; MAI, mitotic activity index; MNA10, mean area of the 10 largest nuclei; P, probability of no significance (<0.05); R, correlation coefficient; SPF, S phase fraction. | |||||||||
| MNA10 | R | 1.00 | 0.74 | 0.67 | 0.71 | 0.62 | 0.40 | 0.60 | 0.56 |
| P | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | ||
| Ki67 | R | 1.00 | 0.82 | 0.69 | 0.53 | 0.45 | 0.55 | 0.56 | |
| P | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | |||
| MAI | R | 1.00 | 0.62 | 0.53 | 0.40 | 0.55 | 0.51 | ||
| P | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | ||||
| p53 | R | 1.00 | 0.46 | 0.33 | 0.44 | 0.47 | |||
| P | 0.000 | 0.000 | 0.000 | 0.000 | |||||
| DI FCM | R | 1.00 | 0.57 | 0.79 | 0.41 | ||||
| P | 0.000 | 0.000 | 0.000 | ||||||
| SPF FCM | R | 1.00 | 0.45 | 0.37 | |||||
| P | 0.000 | 0.000 | |||||||
| DI ICM | R | 1.00 | 0.50 | ||||||
| P | 0.000 | ||||||||
| SPF ICM | R | 1.00 | |||||||
| P | |||||||||