Clinicopathological features of the simian virus 40 (SV40) large T antigen sequence positive hepatocellular carcinomas and 20 carcinomas each from cohorts A and B
| Clinicopathological feature | SV40+ve cohort A cases (n = 5) | SV40–ve cohort A cases (n = 20) | Cohort B cases (n = 20) |
|---|---|---|---|
| *Based on the classification of Edmondson and Steiner.2 | |||
| Age (years) | |||
| Median | 68 | 66.5 | 57 |
| Range | 45–82 | 22–88 | 42–75 |
| Sex | |||
| Male | 4 | 14 | 14 |
| Female | 1 | 6 | 6 |
| Background cirrhosis | |||
| Yes | 4 | 13 | 16 |
| No | 1 | 7 | 4 |
| Tumour grade* | |||
| I/II | 2 | 6 | 9 |
| III/IV | 3 | 14 | 11 |
| Tumour cell type | |||
| Hepatoid only | 4 | 13 | 13 |
| Hepatoid+clear | 1 | 7 | 7 |
| Predominant tumour architecture | |||
| Trabecular | 2 | 12 | 12 |
| Solid | 2 | 3 | 6 |
| Acinar | 1 | 5 | 2 |