Table 1

Study definition of nuclear atypia of junctional melanocytes, adapted from groups of Weinstock et al and Rhodes and colleagues21,22

FeatureNormalMinimalModerateSevere
*Size of melanocyte nucleus compared with the size of basal keratinocyte nucleus (kn).
Nuclear size*<kn>kn2×kn>2×kn
Nuclear variabilityMinimalSomeModerateSevere
ChromatinHomogenous/evenly dispersed, delicateHyperchromaticHyperchromatic/coarsely clumped/irregularity in nuclear contour (thickened or grooved nuclear membrane)Hyperchromatic/coarsely clumped/irregularity in nuclear contour
NucleolusNot visibleNot prominentVisibleProminent and lavender in colour
Amount of cytoplasmScantScantAbundantAbundant