ING1 gene structural mutations in human cancers
| Codon | Position | Mutation | Change | Coding | Rate | Origin | Tissue type | First author (year) |
|---|---|---|---|---|---|---|---|---|
| ca, carcinoma; NLS, nuclear localisation signal; NTS, nucleolar targeting sequence; PHD, plant homeodomain; SCC, squamous cell carcinoma. | ||||||||
| 89 | N-terminus | Silent | G/A | Val | – | Skmel-110 | Melanoma | Campos (2002) |
| 95 | N-terminus | Missense | CCC/TCC | Pro/Ser | 1/422 | Patient | Breast and ovarian ca | Toyama (1999) |
| 101 | N-terminus | Silent | C/T | Asp | – | Skmel-110 | Melanoma | Campos (2002) |
| 166 | C-terminus | Silent | G/A | Arg | 1/442 | Patient | Breast and ovarian ca | Toyama (1999) |
| 172 | C-terminus | Missense | GAG/AAG | Glu/Lys | – | HCT116 | Colon carcinoma | Oki (1999), Ito (2002) |
| 173 | C-terminus | Silent | G/A | Ser | 3/23 | Patient | Head and neck SCC | Gunduz (2000) |
| 188 | NLS/NTS | Silent | G/A | Ser | 18/442 | Patient | Breast and ovarian ca | Toyama (1999) |
| 188 | NLS/NTS | Silent | G/A | Ser | – | MKN28 | Gastric carcinoma | Oki (1999) |
| 188 | NLS/NTS | Silent | G/A | Ser | – | MKN45 | Gastric carcinoma | Oki (1999) |
| 188 | NLS/NTS | Silent | G/A | Ser | 14/71 | Patient | Oral SCC | Krishnamurthy (2001) |
| 192 | C-terminus | Missense | GCC/GAC | Ala/Asp | 1/23 | Patient | Head and neck SCC | Gunduz (2000) |
| 214 | PHD | Missense | GCG/GAG | Ala/Glu | 1/31 | Patient | ESCC | Chen (2001) |
| 215 | PHD | Missense | TGC/TCC | Cys/Ser | 1/23 | Patient | Head and neck SCC | Gunduz (2000) |
| 216 | PHD | Missense | AAC/AGC | Asx/Ser | 1/23 | Patient | Head and neck SCC | Gunduz (2000) |
| 219 | PHD | Silent | C/T | Pro | 1/31 | Patient | Oesophageal SCC | Chen (2001) |
| 223 | PHD | Silent | C/T | Asn | 1/31 | Patient | Oesophageal SCC | Chen (2001) |
| 228 | PHD | Silent | T/C | Cys | 1/442 | Patient | Breast and ovarian ca | Toyama (1999) |
| 233 | PHD | Missense | GTC/ATC | Val/Leu | 1/31 | Patient | Oesophageal SCC | Chen (2001) |
| 236 | PHD | Missense | GGG/GTG | Gly/Val | 1/31 | Patient | Oesophageal SCC | Chen (2001) |
| 239 | PHD | Silent | G/C | Ser | – | Skmel-24 | Melanoma | Campos (2002) |
| 244 | PHD | Silent | T/C | Asn | – | Skmel-24 | Melanoma | Campos (2002) |
| 247 | PHD | Silent | C/A | Pro | – | Skmel-24 | Melanoma | Campos (2002) |
| 253 | PHD | Silent | T/C | Cys | – | Skmel-24 | Melanoma | Campos (2002) |
| 257 | PHD | Silent | G/T | Arg | – | Skmel-24 | Melanoma | Campos (2002) |
| 260 | PHD | Missense | AAC/AGC | Asn/Ser | – | Skmel-24 | Melanoma | Campos (2002) |
| 270 | PHD | Silent | A/G | Lys | – | Skmel-24 | Melanoma | Campos (2002) |
| 270 | PHD | Missense | AAG/AAT | Lys/Asn | 1/31 | Patient | Oesophageal SCC | Chen (2001) |
| 272 | PHD | Silent | A/G | Lys | – | Skmel-24 | Melanoma | Campos (2002) |