Ki-67 immunocytochemistry test performance as indicated by ROC plot
| ASCUS or worse | LSIL or worse | HSIL | |
|---|---|---|---|
| At 95% sensitivity the corresponding specificity is given and vice versa. AUC (area under the curve) indicates diagnostic accuracy. Threshold values are the number of Ki-67 immunopositive cells/1000 cells. | |||
| ASCUS, atypical squamous cells of undetermined significance; CI, confidence interval; HSIL, high grade squamous intraepithelial lesion; LSIL, low grade squamous intraepithelial lesion; ROC, receiver operating characteristic. | |||
| 95% sensitivity | |||
| Specificity | 11% | 26% | 48% |
| Threshold | 0.07 | 0.08 | 0.15 |
| 95% specificity | |||
| Sensitivity | 19% | 22% | 42% |
| Threshold | 1.9 | 1.9 | 1.9 |
| AUC (95% CI) | 0.68 (0.56 to 0.81) | 0.72 (0.60 to 0.85) | 0.86 (0.75 to 0.97) |