Sensitivity, specificity, positive (PPV) and negative (NPV) predictive value for different screening techniques
| Conventional cytology | LBC | HPV testing by PCR | HPV testing by HCII | 0.2 ASCUS | 0.2 HSIL | 0.4 ASCUS | 0.4 HSIL | |
|---|---|---|---|---|---|---|---|---|
| Data from the literature3539 are given in percentages. Complementary diagnostic indices are given for 2 thresholds of Ki-67 immunocytochemistry in 2 different diagnostic circumstances. 0.2/0.4 ASCUS/HSIL represents a threshold of 0.2/0.4 Ki-67 immunopositive cells/1000 cells for the diagnosis of ASCUS/HSIL. | ||||||||
| ASCUS, atypical squamous cells of undetermined significance; HCII, Hybrid Capture II (Digene); HPV, human papillomavirus; HSIL, high grade squamous intraepithelial lesion; LBC, liquid based cytology; ND, no data; PCR, polymerase chain reaction. | ||||||||
| Sensitivity | 52.038 to 68.035 | 61.337 to 87.035 | 88.237 to 91.036 | 73.338 to 10035 | 68.0 | 90.0 | 51.0 | 75.0 |
| Specificity | 52.838 to 95.035 | 82.437 to 93.035 | 78.837 | 62.338 to 87.335 | 61.0 | 61.0 | 73.0 | 73.0 |
| PPV | 23.535 to 60.38 | 15.735 | ND | 14.235 to 88.339 | 87.1 | 66.7 | 88.5 | 71.4 |
| NPV | 43.838 to 99.335 | 99.835 | ND | 62.338 to 10035 | 32.6 | 87.5 | 27.9 | 77.3 |