Histological parameters and grading according to the different systems
| Case | Phenotype | Mitosis | Atypia | Necrosis | Grade20 | Grade19 | Grade23 | Risk24 | Ki-67 |
|---|---|---|---|---|---|---|---|---|---|
| Mitosis refers to the number of mitoses in 30 high power fields (×400 magnification). Atypia: –, no atypia; +, atypia in less than 50% of the tumour cells. Necrosis: –, no necrosis; +, less than 50% of the tumour is necrotic. Grade20, 19, 23 : grading according to the FNCLCC system; GI, GII, and GIII corresponds to grade I, II, and III (scores for atypia, necrosis, and mitosis, respectively)20,22. Grading according to Newman and colleagues19 and de Saint Aubain Somerhausen and colleagues23 : M, malignant. Risk assessment according to Fletcher and colleagues24 : H, high risk of malignant behaviour. Ki-67 represents the number of positive nuclei/1000 cells expressed as a percentage. | |||||||||
| 2 | Spindle | 9/30 | + | – | GI (2+1+2) | M | M | H | 4% |
| 3 | Spindle | 171/30 | + | + | GIII (2+2+4) | M | M | H | 44% |
| 5 | Epithelioid | 8/30 | + | – | GI (2+1+2) | M | M | H | 10% |
| 6 | Epithelioid | 30/30 | + | – | GII (2+1+3) | M | M | H | 15% |
| 14 | Spindle | 10/30 | + | – | GI (2+1+2) | M | M | H | 16% |
| 20 | Spindle | 45/30 | + | + | GIII (2+2+4) | M | M | H | 30% |
| 22 | Mixed | 15/30 | + | + | GII (2+3+2) | M | M | H | 15% |