Summary of the pattern of expression of CD34 and α smooth muscle antigen (αSMA) in fibroblasts in relation to histopathological features
| CD34 | αSMA | ||||||
|---|---|---|---|---|---|---|---|
| Histology | + | − | +/− | + | − | +/− | Total no. duct/lobular units |
| For normal breast, ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS), atypical ductal hyperplasia (ADH), and hyperplasia of usual type (HUT), figures relate to individual duct–lobular units. For fibroadenomas, radial scars, postbiopsy fibrosis, and invasive carcinomas, figures relate to case numbers. | |||||||
| Normal | 301 | 0 | 0 | 0 | 278 | 23 | 301 |
| HUT | 88 | 0 | 0 | 0 | 79 | 9 | 88 |
| DCIS: low | 28 | 21 | 11 | 33 | 16 | 11 | 60 |
| DCIS: intermediate | 22 | 29 | 26 | 52 | 3 | 22 | 77 |
| DCIS: high | 48 | 311 | 39 | 362 | 0 | 36 | 398 |
| LCIS | 12 | 0 | 0 | 0 | 12 | 0 | 12 |
| Invasive carcinoma | 0 | 40 | 0 | 40 | 0 | 0 | 40 |
| Microinvasion | 0 | 6 | 0 | 6 | 0 | 0 | 6 |
| Radial scar | 0 | 21 | 3 | 5 | 4 | 15 | 24 |
| Fibroadenoma | 10 | 0 | 0 | 10 | 0 | 0 | 10 |
| ADH | 3 | 0 | 3 | 0 | 6 | 0 | 6 |
| Apocrine cyst | 11 | 0 | 0 | 0 | 11 | 0 | 11 |
| Postbiopsy fibrosis | 0 | 4 | 0 | 4 | 0 | 0 | 4 |