Homocysteine and vitamin status in all patients with stroke according to MTHFR genotype
| Variable | Genotype (three categories) | Genotype (two categories) | |||||
|---|---|---|---|---|---|---|---|
| CC (N = 55) | CT (N = 52) | TT (N = 13) | p Value (ANOVA) | CC/CT (N = 107) | TT (N = 13) | p Value (ANOVA) | |
| N5MTHF, N5-methyltetrahydrofolate; MTHFR, N5N10-methylenetetrahydrofolate reductase. | |||||||
| Plasma homocysteine (μmol/l) | 11.2 | 11.2 | 11.9 | 0.80 | 11.2 | 11.9 | 0.51 |
| Serum B6 (nmol/l) | 38.1 | 46.5 | 46.6 | 0.22 | 41.7 | 46.1 | 0.59 |
| Serum cobalamin (pmol/l) | 468.7 | 411.6 | 437.0 | 0.31 | 441.4 | 437.0 | 0.97 |
| Total red cell folate (nmol/l) | 652.0 | 692.3 | 523.2 | 0.28 | 671.8 | 523.2 | 0.13 |
| Red cell N5MTHF (nmol/l) | 626.4 | 665.1 | 497.7 | 0.26 | 645.5 | 497.7 | 0.12 |
| Serum folate (nmol/l) | 18.0 | 22.2 | 17.8 | 0.46 | 19.9 | 17.8 | 0.67 |
| Serum N5MTHF (nmol/l) | 17.3 | 20.9 | 15.2 | 0.38 | 18.9 | 15.2 | 0.41 |
| “Immunoassay” red cell folate (nmol/l) | 916.0 | 962.9 | 1064.2 | 0.69 | 943.9 | 1064.2 | 0.45 |