Prevalence of HPV in Edinburgh and Lothian’s routine cervical screening population
| Prevalence of HPV | ||||||||
|---|---|---|---|---|---|---|---|---|
| No. tested (% population) | HPV +ve (%) | HPV –ve (%) | HR-HPV +ve (%) | HR-HPV +ve only (%) | LR-HPV +ve (%) | LR-HPV +ve only (%) | Unknown HPV type (%) | |
| HPV +ve, all who tested HPV DNA positive (includes any individual who tested positive for HR-HPV and or LR-HPV type(s), in addition to those who were positive by PCR but untypable by the LA assay). HPV –ve, all who did not test HPV DNA positive. HR-HPV +ve, all who tested positive for at least 1 HR-HPV type (mixed infections with low risk types are included). HR-HPV +ve only, all who tested positive for a HR-HPV type or types only. LR-HPV +ve, all who tested positive for at least 1 LR-HPV type (mixed infections with high risk types are included). LR-HPV +ve only, all who tested positive for a LR-HPV type or types only. Unknown HPV type, all who tested positive for HPV using real time PCR but hybridised to none of the 27 probes in the LA assay. | ||||||||
| HPV, human papillomavirus; HR, high risk; LA, linear array; LR, low risk; PCR, polymerase chain reaction; U/S, unsatisfactory. | ||||||||
| Dyskaryosis | ||||||||
| Negative | 3089 (89.7) | 392 (12.7) | 2697 (87.3) | 257 (8.3) | 200 (6.5) | 93 (3.0) | 36 (1.2) | 99 (3.2) |
| Borderline | 114 (3.3) | 97 (85.1) | 17 (14.9) | 82 (71.9) | 53 (46.5) | 38 (33.3) | 9 (7.9) | 6 (5.3) |
| Mild | 129 (3.7) | 124 (96.1) | 5 (3.9) | 112 (86.8) | 72 (55.8) | 46 (35.7) | 6 (4.6) | 6 (4.6) |
| High grade | 94 (2.7) | 88 (93.6) | 6 (6.4) | 86 (91.5) | 76 (80.8) | 10 (10.6) | 0 | 2 (2.1) |
| U/S | 18 (0.5) | 4 (22.2) | 14 (77.8) | 3 (16.6) | 3 (16.6) | 0 | 0 | 1 (5.5) |
| Age | ||||||||
| <25 | 734 (21.3) | 308 (42.0) | 426 (58.0) | 260 (35.4) | 171 (23.3) | 111 (15.1) | 22 (2.9) | 26 (3.5) |
| 25–35 | 935 (27.2) | 211 (22.6) | 724 (77.4) | 158 (17.0) | 127 (13.6) | 44 (4.7) | 13 (1.34) | 40 (4.3) |
| 35–45 | 893 (25.9) | 116 (13.0) | 777 (87.0) | 80 (9.1) | 69 (7.7) | 20 (2.2) | 9 (1.0) | 27 (3.0) |
| 45–55 | 603 (17.5) | 55 (9.1) | 548 (90.9) | 33 (5.5) | 29 (4.8) | 8 (1.3) | 4 (0.7) | 18 (3.0) |
| >55 | 279 (8.1) | 15 (5.4) | 264 (94.6) | 9 (3.2) | 8 (2.9) | 4 (1.4) | 3 (1.1) | 3 (1.1) |
| Total | 3444 | 705 | 2739 | 540 | 404 | 187 | 51 | 114 |