Parameter | Mild | Moderate | Severe |
---|---|---|---|
Modified from Weinstock et al.29 | |||
Nuclear size | Approximate size of keratinocyte nucleus | 1–2× keratinocyte nucleus | 2× or greater than keratinocyte nucleus |
Nuclear pleomorphism | Mild | Moderate | Severe |
Chromatin | Hyperchromatic | Hyperchromatic or vesicular | Vesicular |
Nucleolus | Absent or small | Absent or small | Prominent and enlarged |
Cytoplasm | Usually little but sometimes abundant with dusty pigmentation | Usually little but sometimes abundant with dusty pigmentation | Often abundant |