Expansion of Anaplasma phagocytophilum in patient cells and HL-60 cells during the first four days of culture*
| Cell type | Day 1 | Day 2 | Day 3 | Day 4 |
|---|---|---|---|---|
| *The patient’s blood was obtained during the acute phase of infection before doxycycline treatment. Total cell numbers represent the absolute number of viable cells in each flask at the different time points indicated. | ||||
| Numbers of infected patient’s WBCs were significantly different from infected HL-60 cells at each of the first three days of incubation (p<0.001; Pearson χ2). | ||||
| WBC, white blood cells. | ||||
| Total WBC count | 8.6×106 | 1.4×107 | 1.2×107 | 9.8×106 |
| Total infected WBC | 3.4×105 | 6.8×105 | 1.4×106 | 2.2×106 |
| Total HL-60 cell count | 1.4×106 | 4.4×106 | 1.8×107 | 2.5×107 |
| Total infected HL-60 cells | 0 | 0 | 0 (rare) | 2.3×106 |